Northumbria Healthcare GP Update
      9 October 2026  
 

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Changes to ESR and CRP requesting

Many GP’s are aware in most acute medical settings, CRP has largely superseded ESR because it is faster, more sensitive to change, and less affected by confounding factors.

As a result all of the lab profiles eg DMARD testing will replace ESR with CRP. ESR will remain available for now but as the table below shows it has no advantages over CRP: 

 

Feature

CRP

ESR

Detecting acute inflammation

Better

Less sensitive

Monitoring treatment response

Better

Slower

Affected by age/anaemia

Minimal

Significant

Useful in infection

Better

Less useful

Useful in GCA/PMR

Useful

Less sensitive

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